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Research Article
Journal of Integrative Medicine: 2019   Online First
Antioxidant and antihyperlipidemic activity of Costus speciosus against atherogenic diet-induced hyperlipidemia in rabbits
1. Fatma Mohamed Hussein Shediwah (Department of Biology, Faculty of Science, Sana’a University, 13499 Sana’a, Yemen )
2. Khalid Mohammed Naji (Department of Biology, Faculty of Science, Sana’a University, 13499 Sana’a, YemenDepartment of Chemistry, Faculty of Science, Sana’a University, 13499 Sana’a, Yemen E-mail: khalid.m.naji@gmail.com)
3. Hussein Saleh Gumaih (Department of Biology, Faculty of Science, Sana’a University, 13499 Sana’a, Yemen )
4. Fatima A. Alhadi (Department of Biology, Faculty of Science, Sana’a University, 13499 Sana’a, Yemen )
5. Amani Lutf Al-Hammami (Department of Biology, Faculty of Science, Sana’a University, 13499 Sana’a, Yemen )
6. Myrene Roselyn D’Souza (Department of Biochemistry, Mount Carmel College, Bengaluru, Karnataka 560052, India )

ABSTRACT

Objective: An extract of Costus speciosus (CSE), a herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic and ameliorating effects on histopathological changes in atherogenic rabbits.

Methods: Twenty-four male rabbits (Oryctolagus cuniculus) were divided into 4 groups. Three groups were fed a diet containing 3% saturated fat and 1.3% cholesterol for 40 d. One of these was sacrificed on the 40th day and was called the pathogenic (P) group; the other two groups received treatment for another 30 d as follows: one received 0.8 g/(kg·d) of CSE and the other was given 0.01 g/(kg·d) of simvastatin. The normal group was sacrificed on the 70th day and used as a control.

Results: CSE showed radical-scavenging ability. Administration of CSE for a 30-day period resulted in a significant decrease in total cholesterol, triacylglycerol, low-density lipoprotein and aspartate aminotransferase compared to the P group, while levels of hemoglobin, packed corpuscular volume and red blood cells were elevated. With respect to studies performed on the heart, a decrease in malondialdehyde and an increase in reduced glutathione were noted. Total protein increased in the liver, heart and aorta after treatment with CSE and also a marked improvement in histopathological parameters was demonstrated.

Conclusion: The present findings indicate that the C. speciosus rhizome possesses antiatherogenic and antioxidant properties which may provide protective effects against oxidative stress in atherosclerotic rabbits.

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